Retinal (macular) adverse effects have included edema, degeneration, unusual coloring (light pigment stippling to a "bullseye" appearance), loss of foveal reflex, enhanced macular recuperation time belowing direct exposure to an intense light (photostress examination), and raised retinal limit to red light in macular, paramacular, as well as peripheral retinal areas.
![[Ref] Mucocutaneous hyperpigmentation over all extremities, the torso, and also the hairline has actually been stated in a senior male after long-term hydroxychloroquine (the active ingredient included in Plaquenil) usage.](images/img09.jpg)